The drill MOP does a fine job of getting large or non-standard diameter holes made, but what if the hole size is more than twice the diameter of the tool? One obvious way is to interpolate a smaller hole in the center and then either a second interpolation or an internal profile to finish.
A more straightforward method is to use the trochoidal pocket MOP. When the pocket is a circle the toolpath generated is a spiral from the center out to the hole boundary.